Keith at Eurovettes carried out a re-programme of my 2017 GS Auto at the nationals specifically to disable the cylinder deactivation. This was due to the constant swapping to 4 cylinders even at low speed, really annoying. I also have little confidence that driving a car on 4 cylinders in the long term is good for the engine. Lets not forget the only reason this technology was developed was to fudge the MPG and emissions figures to increase GM's overall MPG average across the whole range.
My car is a US import so the deactivation was aggressive. Since the alteration the car feels smoother during acceleration through all gears, pulls better from low speed as there is not the momentary heistancy whilst 8 Cyl's come back on line, and the fuel consumption has only decreased by approx 1 mpg, which I can live with.
The remap is reversible, Keith kept a copy of the original programme/tune.